Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 4.381


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3



Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_85066207 10.003 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_85066265 9.748 FLRT2
fibronectin leucine rich transmembrane protein 2
chr21_+_32706615 7.534 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr3_-_11585264 6.921 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr15_-_38420414 6.618 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr5_+_38481392 6.343 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr8_-_13178327 6.286


chr7_+_22733626 5.997 IL6
interleukin 6 (interferon, beta 2)
chr10_+_17312654 5.962 VIM
vimentin
chr1_-_171441234 5.886 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr21_-_27139563 5.488 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_102340579 5.454 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_115952279 5.411 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr5_+_150000394 5.398 NM_001109974
NM_007286
SYNPO

synaptopodin

chr12_+_13240868 5.376 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240983 5.214 EMP1
epithelial membrane protein 1
chr12_+_13240987 5.198 EMP1
epithelial membrane protein 1
chr7_+_115952325 5.193 CAV1
caveolin 1, caveolae protein, 22kDa
chr2_-_192419896 5.185 SDPR
serum deprivation response
chrX_+_99785818 5.140 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr21_-_27139143 5.040 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_-_25668855 4.973 NM_001004125
TUSC1
tumor suppressor candidate 1
chr7_+_115952074 4.967 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr2_-_192420168 4.902 NM_004657
SDPR
serum deprivation response
chr15_-_38417564 4.775 C15orf52
chromosome 15 open reading frame 52
chr9_+_115396020 4.731 NM_144489
RGS3
regulator of G-protein signaling 3
chr5_+_66160359 4.327 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr12_+_64504408 4.261 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr20_+_8997660 4.234 NM_001172646
PLCB4
phospholipase C, beta 4
chr10_-_17311961 4.234


chr12_-_50871953 4.231 NM_001081492
NM_182507
KRT80

keratin 80

chr4_+_86968069 4.221 ARHGAP24
Rho GTPase activating protein 24
chr20_+_8997791 4.024 PLCB4
phospholipase C, beta 4
chr7_+_22733290 4.022 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr15_+_76889873 4.019 MORF4L1
mortality factor 4 like 1
chr10_+_17311347 3.984 VIM
vimentin
chr18_-_53621277 3.942 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr22_-_22970850 3.938 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr8_-_42184194 3.757 PLAT
plasminogen activator, tissue
chr10_+_17311307 3.638 VIM
vimentin
chr2_+_233961538 3.526 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr10_+_17311242 3.507 VIM
vimentin
chr2_+_66516196 3.504 MEIS1
Meis homeobox 1
chr15_-_32875040 3.488 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr2_-_219404755 3.468 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr8_-_42184350 3.455 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr10_+_17311283 3.452 VIM
vimentin
chr9_-_25668230 3.445 TUSC1
tumor suppressor candidate 1
chr7_-_27153892 3.392 NM_024014
HOXA6
homeobox A6
chr3_+_175641340 3.383 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr2_-_217268492 3.381 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr11_+_113671744 3.345 NM_006169
NNMT
nicotinamide N-methyltransferase
chr12_+_118100977 3.345 NM_014365
HSPB8
heat shock 22kDa protein 8
chr10_+_17311282 3.281 VIM
vimentin
chr6_-_28429950 3.210 NM_145909
ZNF323
zinc finger protein 323
chr5_-_73973004 3.200 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr16_+_56219802 3.127 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chrX_+_99786044 3.121 SRPX2
sushi-repeat containing protein, X-linked 2
chr1_-_151804929 3.100 NM_005978
S100A2
S100 calcium binding protein A2
chr19_-_8581559 3.009 NM_030957
ADAMTS10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr21_+_45699830 2.958 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr11_-_118716736 2.926 C1QTNF5
MFRP
C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein
chr2_-_216008689 2.901 FN1
fibronectin 1
chr17_-_74432671 2.889 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_+_1580504 2.845 WDR81
WD repeat domain 81
chr2_+_66516020 2.797 NM_002398
MEIS1
Meis homeobox 1
chr10_+_17310475 2.781 VIM
vimentin
chr4_+_81406765 2.763 NM_004464
NM_033143
FGF5

fibroblast growth factor 5

chr10_+_17311788 2.760 VIM
vimentin
chr17_-_74432800 2.731 TIMP2
TIMP metallopeptidase inhibitor 2
chrX_-_53327473 2.713 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr7_-_5429702 2.691 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_-_151852128 2.680 NM_080388
S100A16
S100 calcium binding protein A16
chr15_-_66511488 2.639 NM_001004439
ITGA11
integrin, alpha 11
chr12_+_123339662 2.630 NM_181709
FAM101A
family with sequence similarity 101, member A
chr12_+_56406296 2.608 LOC100130776
hypothetical LOC100130776
chr17_-_74433048 2.607 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr5_-_16989371 2.485 NM_012334
MYO10
myosin X
chr11_+_59279481 2.432 STX3
syntaxin 3
chr5_-_16989290 2.413 MYO10
myosin X
chr5_-_111120817 2.411 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr6_+_39868770 2.387 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_+_201862548 2.376 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr1_+_31659246 2.337 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr9_-_129656413 2.306 ENG
endoglin
chr3_+_8750485 2.279 NM_033337
NM_001234
CAV3

caveolin 3

chr9_-_8723893 2.262 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chrX_-_128616594 2.259 NM_017413
APLN
apelin
chr10_+_17311962 2.230 VIM
vimentin
chr5_-_111120764 2.199 C5orf13
chromosome 5 open reading frame 13
chr20_+_19903778 2.199 RIN2
Ras and Rab interactor 2
chr3_-_31997738 2.198 OSBPL10
oxysterol binding protein-like 10
chr1_-_32036802 2.165 SPOCD1
SPOC domain containing 1
chr10_+_11905316 2.155 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr8_-_13178399 2.134 DLC1
deleted in liver cancer 1
chr4_-_66218777 2.128 EPHA5
EPH receptor A5
chr7_+_100557098 2.107 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr15_-_38000379 2.101 NM_007223
GPR176
G protein-coupled receptor 176
chr9_+_130719034 2.062 LRRC8A
leucine rich repeat containing 8 family, member A
chr1_+_201862845 2.061 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr9_-_78710698 2.046 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr12_-_24947233 2.032 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr1_-_159435440 2.023 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr5_+_72287625 2.018


chr19_+_54068373 2.017 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr1_+_149779384 1.991 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr5_+_72287630 1.972 FCHO2
FCH domain only 2
chr5_-_111120929 1.969 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chrX_-_13866451 1.953 GPM6B
glycoprotein M6B
chr10_+_86174665 1.936 FAM190B
family with sequence similarity 190, member B
chr5_-_54317102 1.922 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr5_+_72287509 1.905 NM_001146032
NM_138782
FCHO2

FCH domain only 2

chr10_-_100164877 1.899 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr1_-_32036858 1.882 SPOCD1
SPOC domain containing 1
chr12_-_53099203 1.845 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_+_185171337 1.843 NM_194250
ZNF804A
zinc finger protein 804A
chr2_-_218551786 1.829 TNS1
tensin 1
chr5_-_172130766 1.821 NM_004417
DUSP1
dual specificity phosphatase 1
chr6_+_132170847 1.814 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_-_149611768 1.813 NM_003944
SELENBP1
selenium binding protein 1
chr17_-_77394872 1.790 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr6_+_132170888 1.777 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_+_159435728 1.774 NM_004550
NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
chr5_-_111121150 1.766 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr10_-_128066935 1.714 ADAM12
ADAM metallopeptidase domain 12
chrX_-_13866366 1.713


chr14_-_22515725 1.706 JUB
jub, ajuba homolog (Xenopus laevis)
chr9_-_129656581 1.706 ENG
endoglin
chr1_-_32940850 1.705 SYNC
syncoilin, intermediate filament protein
chr10_-_105604942 1.704 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr1_+_213245507 1.692 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr17_-_74487527 1.676 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr9_-_112840064 1.664 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr8_+_55533047 1.662 NM_022454
SOX17
SRY (sex determining region Y)-box 17
chr1_-_23683214 1.655 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr10_-_126097444 1.655 OAT
ornithine aminotransferase
chr5_+_148941228 1.640 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr1_-_151866593 1.627 NM_001024211
S100A13
S100 calcium binding protein A13
chr1_-_171286634 1.619 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr16_-_19803606 1.608 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr11_-_62213577 1.599 LRRN4CL
LRRN4 C-terminal like
chr9_-_129656778 1.598 ENG
endoglin
chr10_-_126097483 1.594 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr15_-_81412354 1.593 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr19_+_54068300 1.542 PPP1R15A
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr4_+_124540114 1.528 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr10_-_49993425 1.524 NM_001031746
NM_144984
C10orf72

chromosome 10 open reading frame 72

chr6_-_35804337 1.516 NM_001145775
FKBP5
FK506 binding protein 5
chr1_-_16217025 1.504 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr9_+_27099138 1.496 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr22_-_37970902 1.492 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
chr12_-_53099269 1.488 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_+_238321794 1.482 NM_020066
FMN2
formin 2
chr6_-_47030492 1.469 NM_015234
GPR116
G protein-coupled receptor 116
chr16_+_2025922 1.444 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr9_+_112470871 1.437 NM_001166280
NM_001166281
NM_005592
MUSK


muscle, skeletal, receptor tyrosine kinase


chr17_+_24394281 1.430 PIPOX
pipecolic acid oxidase
chr3_+_191714533 1.412 NM_001167928
NM_001167929
NM_001167930
NM_001167931
NM_002182
NM_134470
IL1RAP





interleukin 1 receptor accessory protein





chr1_+_183970093 1.405 NM_031935
HMCN1
hemicentin 1
chr10_-_128067052 1.399 ADAM12
ADAM metallopeptidase domain 12
chrX_-_83644054 1.390 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr11_-_62213946 1.382 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr2_+_228045121 1.377 NM_001135187
NM_001135188
NM_001135189
NM_004504
AGFG1



ArfGAP with FG repeats 1



chrX_+_102518064 1.370 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr11_-_85074848 1.355 NM_152723
CCDC89
coiled-coil domain containing 89
chr19_+_50004134 1.354 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr9_-_23811477 1.338 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_23811808 1.337 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_23811842 1.333 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr11_-_65082705 1.315 LTBP3
latent transforming growth factor beta binding protein 3
chr1_-_245342150 1.308 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr15_-_88159061 1.308 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chrX_-_54539043 1.302 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr17_-_39265965 1.289 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr4_+_123873306 1.253 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr4_+_38545741 1.247 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr1_+_219026661 1.244 NM_022746
MOSC1
MOCO sulphurase C-terminal domain containing 1
chr3_+_35656012 1.244 ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_+_75507750 1.235


chr15_-_47042932 1.221 NM_203349
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr19_+_40322231 1.219 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr20_-_23566325 1.217 NM_000099
CST3
cystatin C
chr1_-_86394695 1.216 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr22_+_40093245 1.209 NM_001145398
TEF
thyrotrophic embryonic factor
chr10_+_122206455 1.206 NM_001030059
PPAPDC1A
phosphatidic acid phosphatase type 2 domain containing 1A
chr3_+_31998269 1.181 NM_001137674
ZNF860
zinc finger protein 860
chr1_+_201862552 1.178 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr17_-_15104768 1.161 NM_153322
PMP22
peripheral myelin protein 22
chr11_-_6298284 1.145 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr3_-_58538110 1.144 FAM107A
family with sequence similarity 107, member A
chr3_+_127743868 1.143 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr9_-_129656830 1.142 NM_000118
NM_001114753
ENG

endoglin

chr1_+_160868932 1.137 DDR2
discoidin domain receptor tyrosine kinase 2
chr20_+_19815075 1.136 RIN2
Ras and Rab interactor 2
chr14_+_23937766 1.134 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr19_+_55072493 1.133 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr17_+_72795567 1.132 NM_001113492
SEPT9
septin 9
chr10_-_128067001 1.124 ADAM12
ADAM metallopeptidase domain 12
chr1_+_160868822 1.122 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr17_+_74542066 1.106 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 6.92e-05 GO:0048731 system development
1.40 1.06e-04 GO:0048856 anatomical structure development
1.34 3.90e-04 GO:0032502 developmental process
1.35 8.16e-04 GO:0007275 multicellular organismal development
1.53 2.92e-03 GO:0023051 regulation of signaling
1.57 4.08e-03 GO:0009966 regulation of signal transduction
1.53 9.14e-03 GO:0009653 anatomical structure morphogenesis
1.96 2.50e-02 GO:0072358 cardiovascular system development
1.96 2.50e-02 GO:0072359 circulatory system development
1.22 4.47e-02 GO:0032501 multicellular organismal process
1.42 4.85e-02 GO:0048513 organ development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.60 4.15e-03 GO:0044421 extracellular region part
1.96 1.20e-02 GO:0043005 neuron projection
1.34 2.90e-02 GO:0044459 plasma membrane part
2.42 3.48e-02 GO:0043025 neuronal cell body
2.23 4.68e-02 GO:0045177 apical part of cell

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.65 2.24e-02 GO:0030165 PDZ domain binding
1.15 3.94e-02 GO:0005515 protein binding
9.40 4.39e-02 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity